BECN1 and cancer: The molecular changes underlying curcumin-mediated autophagic responses were also documented for cutaneous T-cell lymphoma to be relevant to the degradation of beclin-1, which is a component of class III phosphatidylinositol 3-kinase (IIIPI3K) and has an up-regulating effect on autophagosome [41], and thereby the accumulation of microtubule-associated protein-1 light chain 3 (LC3I), which promotes the death of the cancer cells [42].