Given the fact that curcumin’s pleiotropic activity on cancer prevention [2–4], several earlier studies have further illustrated this interest of combinational using of curcumin with 5-Fu, by showing its sensitizing effect against 5-Fu resistance in varied cancer cell types such as human gastric cancer cells through inhibition of the NFκB survival-signaling pathway [43], or particularly in different sub-types of colon cancer cell lines, via miRNA-induced suppression of epithelial-to-mesenchymal transition [26], or the modulation of EGFR and IGF-1R. Here, NFKB1 is linked to colonic neoplasm.