The immunohistochemical detection of ATRX/DAXX downregulation, strongly correlates with ALT in tumor specimen of Pancreatic neuroendocrin tumors [65], in hepatic angiosarcomas [66] and leyomiosarcoma [67], suggesting that this complex could be employed in the clinical practice as a surrogate marker of ALT phenotype. This evidence concerns the gene GPT and liver angiosarcoma.