PML and Takayasu arteritis: While TA tumors can be easily detected by TRAP assay, ALT can be deduced from the presence of different phenotypical characteristics: the absence of Telomerase activity, the presence of very long and heterogeneous telomeres, ALT-associated PML bodies (APBs), telomeric and GC-rich minisatellite instability, telomeric-sister chromatid exchange (T-SCE), and extrachromosomal telomeric DNA [41].