P2RY12 and myeloid sarcoma: To investigate the binding of PET tracers and their ability to predict and follow the change of P2Y12R and P2X7R expression, we performed autoradiography binding experiment using a carbon-11-labeled specific P2Y12R tracer ([11C]P2Y12R-ant) and tritium-labeled P2X7R-specific tracer ([3H]A-740003) for binding to EAE and human MS post-mortem tissues.