The second cluster includes 12 genes up-regulated at t=+4 and related to connective tissue disorders and inflammatory diseases (GYG1, PDXK, RETN, C3, IL27, TLR4, IL1RN, ICAM1, CXCL13, C3AR1, FAS, SOD2, and TLR4). Here, SOD2 is linked to connective tissue disorder.