The second cluster includes 12 genes up-regulated at t=+4 and related to connective tissue disorders and inflammatory diseases (GYG1, PDXK, RETN, C3, IL27, TLR4, IL1RN, ICAM1, CXCL13, C3AR1, FAS, SOD2, and TLR4). This evidence concerns the gene C3AR1 and connective tissue disorder.