CAT and obesity due to melanocortin 4 receptor deficiency: Of the set of 32 genes responsible for the significant enrichment for obesity in the LHvsLN comparison (Additional file 1: Figure S8), the gene with most published evidence of association with obesity was the insulin receptor gene Insr (ENSRNOG00000029986) (Additional file 1: Table S6); Cat (ENSG00000121691) was the human gene of that list assigned to the promoter with the greatest number of SSVs (58 SSVs) overlapping the HVRs.