This cognitive impairment became clinically apparent in over half of the patients after 3 months of active FBDS and correlated well with medial temporal lobe imaging changes, frontotemporal EEG activity and serum hyponatraemia, likely involving the LGI1-expressing, ADH-secreting hypothalamic neurons (Irani et al., 2012). Here, LGI1 is linked to Cognitive impairment.