Increased expression of proteins involved in sex steroid inactivation (AKR1C1, AKR1C2, AKR1C3, AKR1B10) in DIO1 re-expressing renal cancer cells might indicate decreased local production of androgens, which have been linked to proliferation of renal and other cancers expressing androgen receptor. Here, AKR1B10 is linked to renal carcinoma.