This analysis, performed on transcriptomic data of 468 patients, showed that altered expressions of AKR1C1, AKR1C2, SLC7A5, NMI, PLAU, TBC1D2, TGM2, and WIZ correlated with poor survival of ccRCC patients. The gene discussed is AKR1C2; the disease is nonpapillary renal cell carcinoma.