d = transplantation day; * = p < 0.05; ** = p < 0.01The significant increase of endothelial activation markers in the GVHD group was observed for s-TM Ag at 24 and 38 days and for FVIII:C at 90 days after transplantation (Fig 3A and 3B). Here, THBD is linked to graft versus host disease.