GRB2 and ovarian cancer: In addition, panduratin A down-regulated CD63, which was found as a positive correlate with the invasiveness of ovarian cancer [160], growth factor receptor-bound protein 2 (GRB-2), intercellular adhesion molecule 2 (ICAM-2) and stabilin 1 (STAB-1) that are implicated in adhesion, migration and tube formation of endothelial cells.