Administration of GLP-1 (0.4 pmol/kg/min) for 2 h reduced 8-iso-prostaglandin F2α (8-iso-PGF2α) and nitrotyrosine (oxidative stress markers) in plasma during a hypoglycemia or hyperglycemia clamp in both type 1 and type 2 diabetic patients [108,109]. This evidence concerns the gene GLP1R and Hyperglycemia.