NFE2L2 and pancreatic insulinoma: Nrf2 knockdown in a mouse insulinoma cell line (MIN6) or pancreatic islets isolated from Nrf2-knockout mice are vulnerable to arsenic-induced cell damage [93], and pharmacological activation of Nrf2 improves islet yield and islet function after transplantation [94], indicating that Nrf2 plays a significant role in the protection of pancreatic beta cells from oxidative stress.