TSC2 and tuberous sclerosis: ASD is diagnosed in as many as 50% of children with ASD (Jeste, Sahin, Bolton, Ploubidis, & Humphrey, 2008), therefore, we looked closely for signs of TSC in the 18 children in our population with rare variants in TSC2. All 18 children with TSC2 variants underwent a thorough skin examination with none having 3 or more hypomelanotic macules.