While a lack of APOE and RCT might play a pathogenic role due to reduced efficacy of cholesterol and β-amyloid clearance in atherosclerosis (Mahley et al. 2009) and Alzheimer disease (Bales et al. 2009; Mahley et al. 2009), excessive APOE and RCT might be responsible for IIRC activation and chronic inflammation in AMD. Here, APOE is linked to early-onset autosomal dominant Alzheimer disease.