In AMD, APOA-I levels are elevated in the vitreous (Koss et al. 2014) and serum (Paun et al. 2015) and APOE accumulates in drusen (Klaver et al. 1998) and is strongly expressed by subretinal MPs (Levy et al. 2015a). This evidence concerns the gene APOA1 and age-related macular degeneration.