The senescent phenotypes associated with Lamin A/C alterations can be due to mutations in the lamin-encoding gene LMNA resulting in familial lipodystrophy FPLD2 associated with early atherosclerosis (Bidault et al. 2013), or treatment with some anti-HIV antiretroviral drug (ART), such as protease inhibitors (PI) (Lefèvre et al. 2010). The gene discussed is LMNA; the disease is atherosclerosis.