APOE and age-related macular degeneration: Curiously, the association with AMD is inversed: APOE2-allele carriers are at increased risk for developing late AMD (OR = 1.83 for homozygote carriers), while the APOE4-allele protects for AMD (OR = 0.72 per haplotype) compared to the most common APOE3-allele recently confirmed in a worldwide study comprising 20,000 subjects (McKay et al. 2011).