In mice, we showed that subretinal MPs of Cx3cr1GFP/GFP-mice that develop subretinal inflammation and cardinal features of AMD (Combadiere et al. 2007) express similar high levels of APOE (Levy et al. 2015a), but also IL-6 (Levy et al. 2015a) and CCL2 (Sennlaub et al. 2013). Here, APOE is linked to age-related macular degeneration.