We and others have focused on key players in CKD-MBD such as 25-hydroxyvitamin D (25D) and the bone-derived hormone FGF23, because these are important determinants of levels of serum 1,25-dihydroxyvitamin D (1,25D), which is a crucial hormone that contributes to bone integrity [3] to prevent falls in patients with CKD [4]. This evidence concerns the gene FGF23 and Marchiafava-Bignami disease.