Therefore, besides its contribution to better understanding the molecular mechanisms that explain the gating properties of the splits, our work may provide some additional clues for a better understanding of the role of regions functionally involved in VSD-PD coupling in Kv11.1 and other voltage-dependent potassium channels which, when altered, lead to a number of disorders, such as long QT syndrome, episodic ataxia and epilepsy [5, 42]. This evidence concerns the gene KCNH2 and epilepsy.