Fig. 2 shows that deSUMOylation of HSF2 by ANGII-mediated MEL18 activation leads to cardiac hypertrophy. Fig. 3 represents that angiotensin II receptor blockers (ARBs) alleviates the cardiac dysfunction in spontaneous hypertensive rats (SHRs). Fig. 4 shows that MEL18-mediated HSF2-IGF-IIR pathway is upregulated in hypertension human heart, compared to health human heart. The gene discussed is HSF2; the disease is hypertensive disorder.