The Hyperglycemia and Its Effect after Acute Myocardial Infarction on Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus (HEART2D) study was designed to target postprandial glucose with short-acting insulin as compared to fasting glucose with basal insulin in patients with acute MI occurring within 3 weeks of randomization [74]. The gene discussed is INS; the disease is acute myocardial infarction.