ACE and heart failure: In the diabetes substudy of the PARADIGM-HF (Prospective Comparison of ARNI [Angiotensin Receptor-Neprilysin Inhibitor] with ACEI [Angiotensin-Converting-Enzyme Inhibitor]) to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial, sacubitril/valsartan was compared with enalapril in 3778 subjects with New York Heart Association Classes II-IV heart failure and T2D.