VEGFA and glioblastoma: More recently it has been hypothesized that dual inhibition of VEGF and Ang-2 signaling respectively with TKI cediranib and MEDI3617 (an anti-Ang-2-neutralizing antibody) could prolong the temporal window of vascular normalization and thereby enhances the survival benefit of anti-VEGF therapy in two orthotopic murine model of GBM (Peterson et al., 2016).