CD274 and neoplasm: More recently, a preclinical study provided evidences that anti-PD-1 or anti PD-L1 therapy sensitized and prolonged the efficacy of antiangiogenic therapy, and conversely, antiangiogenic therapy improved anti-PD-L1 treatment by supporting vascular changes, such as vessel normalization and high endothelial venules formation, that facilitate enhanced cytotoxic T cell infiltration and subsequent tumor cell destruction (Allen et al., 2017).