In particular, are under clinical investigation the efficacy of the combination of galunisertib, a small molecule inhibitor of TGFβRI, with sorafenib and ramucirumab in HCC and PF-03446962, a monoclonal antibody against TGFβ, in combination with regorafenib in CRC. The gene discussed is TGFB1; the disease is colorectal carcinoma.