VEGFA and neoplasm: VEGF was identified as the master tumor angiogenic inducer and “sprouting angiogenesis” (i.e., the formation of capillaries from pre-existing vessels by endothelial sprouting triggered by angiogenic inducers and followed by formation of endothelial tubes, which undergo maturation by pericyte recruitment and extracellular matrix remodeling) as the almost unique mode to sustain the tumor vascularization (Bussolino et al., 1997).