Individuals with suspected inherited syndromes that confer risk for additional organ manifestations beyond the bone marrow, such as Noonan syndrome or GATA2 deficiency, should also be referred to additional specialists as appropriate (e.g., a medical geneticist for Noonan syndrome; infectious disease specialist for GATA2 deficiency), if they have not already been evaluated by one for comprehensive management of other non-malignant conditions. This evidence concerns the gene GATA2 and hyperinsulinemic hypoglycemia, familial, 4.