NLRP3 and kidney disorder: We have previously shown that deletion of Pr2x7 gene attenuated renal disease in mice fed a HFD and that this was associated with blunted upregulation of the NLRP3 inflammasome components NLRP3, ASC, procaspase-1, pro-IL-1β, and pro-IL-18 and reduced the formation of mature caspase-1 [16].