Csak et al. found that both bone marrow- (BM-) derived and non-BM-derived cells contributed to NLRP3 inflammasome activation in a myeloid differentiation primary response gene 88- (MyD88-) dependent manner in NASH induced by MCD diet, though only BM-derived cell-specific MyD88-deficiency attenuated liver injury [45]. This evidence concerns the gene MYD88 and metabolic dysfunction-associated steatohepatitis.