IFNλ1, 2, 3 treatment of human monocyte-derived macrophages inhibits infection via JAK–STAT (73, 74)Pretreatment of human primary CD4 T cells with IFNλ1 or IFNλ2 reduced HIV integration and posttranscriptional events, but IFNλ1 was not negatively correlated with HIV levels in vivo (75). The gene discussed is SOAT1; the disease is infection.