To determine potential of PKD inhibitors as therapeutics after the disease has commenced, we administered CID755673 (15 mg/kg) or vehicle by intraperitoneal (IP) injection to rats in early and late stages after the initiation of pancreatitis (i.e., 30 min after 1st and 4th of IP injection of cerulein). This evidence concerns the gene PRKD1 and pancreatitis.