Consistent with our in vitro experimental results, selective and specific inhibition of PKD catalytic activity and Ser 916 autophosphoryltion by either inhibitor (Figure 3) resulted in strikingly decreased NF-κB activation in early stage of acute pancreatitis in rats pre-treated with CID755673 or CRT0066101 compound (Figure 4). This evidence concerns the gene NFKB1 and acute pancreatitis.