Combining with our previous reports (Yuan et al., 2008, 2012; Thrower et al., 2011; Yuan and Pandol, 2016) that identified PKD as an early convergent target of PKCδ and ε signaling in NF-κB activation in exocrine pancreas, we summarized our findings in Figure 8 to show the signaling pathways of PKD mediating NF-κB activation in pancreatitis. The gene discussed is PRKD1; the disease is pancreatitis.