NFKB1 and acute pancreatitis: Multiple experimental models of pancreatitis have shown that NF-κB activation in acinar cells is one of earliest events in acute pancreatitis and the inhibition of NF-κB activation alleviates the severity of the disease (Gukovsky et al., 1998, 2003; Satoh et al., 1999; Vaquero et al., 2001).