CCK and pancreatitis: Pancreatic acini freshly prepared from rat were incubated with 25 μM CID755673 or 10 μM CRT0066101 for 2 h followed by challenging with a high dose of the pancreatic secretagogues CCK (100 nM) or CCh (200 μM) which were known to induce pancreatitis pathologies in acini in vitro (Gukovsky et al., 2003; Yuan et al., 2008, 2012; Thrower et al., 2011).