Similar to the in vitro experimental results shown above, the two inhibitors also suppressed PKD Ser916 autophosphorylation (Figure 3B) but had no effect on PKD/PKD1 Ser744/748 phosphorylation which was majorly through PKC-dependent pathways in pancreatitis (Figure 3B), confirming the selectivity and specificity of CID755673 and CRT0066101 targeting PKD in vivo. This evidence concerns the gene PRRT2 and pancreatitis.