FLT3 and acute myeloid leukemia: In both adult and childhood AML, the incidence of FLT3 ITD (15–37 and 10–21% respectively) was higher compared to FLT3 TKD (10 and 7%) (Cloos et al., 2006; Thol et al., 2011; Damm et al., 2012; Grossmann et al., 2012; Cancer Genome Atlas Research, 2013; Liang et al., 2013; Kao et al., 2014; Rubio et al., 2016; Shiba et al., 2016).