RUNX1 and acute myeloid leukemia: RUNX1 mutations are more prevalent in AML without complex karyotype, with 5–18% in adult AML (Gaidzik et al., 2011; Grossmann et al., 2012; Cancer Genome Atlas Research, 2013) and 1–6% in childhood AML (Liang et al., 2013; Al-Kzayer et al., 2014).