Also, mutations in DNMT3A, IDH1, TET2, FLT3 ITD, MLL, and EZH2 are associated with poorer prognosis, whilst mutations in RUNX1, WT1, and TP53 are predictive of the worst outcomes and increased relapse risk in both adult and childhood AML. Here, DNMT3A is linked to acute myeloid leukemia.