EZH2 and acute myeloid leukemia: 3-Deazaneplanocin (DZNep), an EZH2 inhibitor, may serve as a potential drug for consolidation or maintenance therapy in AML patients to decrease the chance of relapse by eliminating the cancer stem cells which are resistant to conventional chemotherapy such as cytarabine and daunorubicin (Miranda et al., 2009; Horton and Huntly, 2012).