IDH2 and acute myeloid leukemia: IDH1 and IDH2 mutations were rarely detected in childhood AML, with a frequency of 0–1 and 1–2% respectively, but a higher incidence was seen in children with CN-AML (Ho et al., 2010, 2011; Andersson et al., 2011; Damm et al., 2011; Liang et al., 2013).