In addition, the activities of the hydroxyacyl-co enzyme A deshydrogenase (HADHA, an enzyme involved in the fatty acid oxidation) and of the 3-oxoacid-CoA transferase 1 (SCOT, an enzyme involved in the ketolysis) were increased in 3-month-old 3xTg-AD female mice when compared to WT mice. The gene discussed is OXCT1; the disease is Alzheimer disease.