TIA1 and amyotrophic lateral sclerosis: Recently, dominant mutations in T-cell restricted intracellular antigen 1 (TIA1), which is an RNA-binding protein involved in SMN2 exon 7 splicing (Singh et al., 2011), were shown to play a causative role in ALS (Mackenzie et al., 2017), while TIA1 knockout modifies phenotypes of mild male SMA mice (Howell et al., 2017).