TARDBP and amyotrophic lateral sclerosis: While they may have a narrow applicability window due to small percentages of genetically determined ALS, given pathological commonalities, such as cytoplasmic TDP-43 sequestration (Neumann et al., 2006) and possible involvement of wild-type SOD1 misfolding in disease (Bosco et al., 2010), there is scope for broader application.