We suggest that MG administration could be an alternative approach to the streptozotocin model to study the mechanisms of painful diabetic neuropathy, as streptozotocin directly activates TRPA1 (Andersson et al., 2015) and depletes resident immune cells in the PNS (Hidmark et al., 2017) to produce hyperalgesia before the development of hyperglycemia. Here, TRPA1 is linked to diabetic neuropathy.