The genealogic studies suggest that the Swedish LQTS founder mutation KCNQ1/p.Y111C [11, 14] shared an origin and segregated with the HFE mutation [2] in a river valley population of northern Sweden (Figs 1, 2, and 3 and Additional file 1: Figure S1 and Figure S2) . The gene discussed is KCNQ1; the disease is familial long QT syndrome.