PSEN2 and Alzheimer disease: We prepared complexes of human full length PSs and AD related mutants with lipid-like fos-choline detergents based on the results of the presenilin expression study20 to investigate the effect of the lipophilic environment on folding and stability of the proteins, because our previous finding that presenilin 2 exhibited a low melting temperature for tertiary structure (34 °C), but relatively stable secondary structure (Tm 55 °C) pointed at thermally induced refolding.