AURKA and Familial prostate cancer: We have also previously shown that the expression of AURKA is increased with androgen stimulation in LNCaP-ARhi cells expressing high levels of AR18 (Supplementary Figure S2), and ChIP-seq analyses have indicated a putative prostate cancer specific ARBS in the promoter as well as in the intronic region of the gene20–23 (Supplementary Table S1, Supplementary Figure S3).