FOXO3 and neoplasm: As shown in Supplementary Fig. 6a, b, whereas overexpression of mutant p53 G245D greatly promoted the tumor growth when compared to the control cells, overexpression of FOXO3a (Supplementary Fig. 6a) or downregulation of FOXM1 (Supplementary Fig. 6b) in mutant p53 G245D UM-SCC-1 cells showed no significant impact on the tumor growth rate.