FOXO3 and neoplasm: In further support of the regulatory role of mutant p53 G245D in FOXO3a-FOXM1 signaling, IHC staining of lung metastatic tumor lesions also showed that while mutant p53 G245D decreased FOXO3a’s (Fig. 7e, f) but increased FOXM1’s (Fig. 7g, h) nuclear staining, further overexpression of FOXO3a in mutant p53 UM-SCC-1 cells (Fig. 7e) decreased the mutant p53-induced FOXOM1 nuclear staining (Fig. 7g, h).