TP53 and neoplasm: In further support of FOXO3a’s role, in a 3D cell culture, G245D mutant p53 cells exhibited a more infiltrative phenotype with projecting protrusions, whereas the vector control UM-SCC-1 cells mainly formed round-shaped tumor spheroids (Fig. 1a); the control phenotype was further suppressed by overexpressing FOXO3a, leading to reduced formation of projecting protrusions (Fig. 6c, d).