Given our observations that GOF mutant p53s inhibit AMPK [16] but promote FOXM1 expression (Figs. 1 and 2), the inverse correlation of FOXM1 expression and AMPK activation observed here (Figs. 1e and 2a, e) suggests that AMPK may be able to regulate FOXM1 expression in HNSCC cells. This evidence concerns the gene FOXM1 and head and neck squamous cell carcinoma.