TRBV18 and Cowden disease: When considering unique clonotypes,TRBV5, TRBV6, TRBV7 and TRBV18 family genes were more frequently used in patient total PBMC repertoires after gluten challenge while only TRBV6 showed increased usage in one patient’s biopsy repertoire during active CD (Fig. 2A and B; for all TRBV-gene results see Supplementary Fig. S3).