Hardy et al. have reported such diversity at the TCR level in a smaller repertoire of CD4+ IFNg+ T-cells specific to the dominant HLA-DQ2.5-glia-α1a/α2 epitope in both children and adult CD patients, with adult patients not showing any more narrowing of the repertoire specific to the epitope compared to that of children despite more exposure to gluten18. Here, IFNG is linked to Cowden disease.