To test whether the anti-cancer effect of econazole in lung cancer is as potent as other PI3K inhibitors, we compared its cytotoxicity with two known PI3K inhibitors (PI3Kα-selective inhibitor alpelisib BLY719 and pan-PI3K inhibitor buparlisib BKM120) in H661 cells. The gene discussed is PIK3CA; the disease is lung cancer.