Combined analysis of CD3 and CD8 cells in the IM and CT (Immunoscore) is a promising additional prognostic parameter in colorectal cancer, which categorizes the densities of each of these cell types in both IM and CT as low (0 points) or high (1 point), thus yielding a five-tiered classification (0–4). The gene discussed is CD8A; the disease is colorectal cancer.