Characteristic intron inclusion/exclusion events modulated by CELF1 (i.e., involving INSR, SERCA1, FXR1, FAM188A, ANK2, ACTN1, MEF2A, and PPFIBP1)38 were addressed by quantitative reverse transcription-PCR (qRT-PCR) in eight independent melanoma cell lines. The gene discussed is ANK2; the disease is melanoma.