Curiously, out of the 348 RBPs altered in melanoma, only seven (CSTF2, DDX3X, DKC1, EIF1AX, GNL3L, MEX3C, and RBMX) were included in a RBP-cancer signature recently described in 16 non-melanoma tumor types4 (Supplementary Table 2). The gene discussed is DDX3X; the disease is melanoma.