Given that the N-terminal portion of Nup98 is required for the proper recruitment of the WSC complex to chromatin and H3K4me3 in wild-type HPCs (Figs. 2, 4), we predicted that Nup98 translocation proteins promote AML through aberrant recruitment of H3K4me3 activity to developmental genes such as HOXA and HOXB cluster genes and Meis1 (Fig. 5A). Here, NUP98 is linked to acute myeloid leukemia.