Understanding how Nup98 regulates expression of target genes remains an extremely relevant question, as many patients suffering from acute myeloid leukemia (AML) harbor mutations in which the N terminus of Nup98 is translocated with the C terminus of one of ∼30 different translocation partners (Xu and Powers 2009; Gough et al. 2011; Franks and Hetzer 2013; Simon and Rout 2014). This evidence concerns the gene NUP98 and acute myeloid leukemia.