Interestingly, the ability of the Nup98-Nsd1 fusion to stimulate unusual H3K4me3 patterns appears to be limited to a subset of binding sites, as we only saw a correlation between Nup98-Nsd1 binding and H3K4me3 at developmental sites that have been previously linked to AML. This evidence concerns the gene NSD1 and acute myeloid leukemia.