The situation could be rather different in BC, where p53 is relatively less frequently mutated compared with other types of tumors (Gasco et al., 2002; Bertheau et al., 2013; Dumay et al., 2013), in particular in luminal subtypes, and loss of WT p53 activity may depend on alterations of regulatory pathways of p53 stability (Dumay et al., 2013). The gene discussed is TP53; the disease is breast cancer.