TP53 and cancer: However, when the luminal subtype of cancers was considered, which accounts for ∼70% of all BCs and is enriched in p53 WT tumors (Dumay et al., 2013), a low Numb-1/2 status emerged as an independent predictor of the risk of metastasis in multivariable analysis both in the entire luminal subcohort and in the p53-WT sub-subcohort (Fig. 10 G).