The alternative splicing of Numb is the subject of increasing interest because Numb is involved in major types of human cancers, including breast and lung cancer (Pece et al., 2004; Colaluca et al., 2008; Westhoff et al., 2009; Rennstam et al., 2010; Sheng et al., 2016; Tosoni et al., 2017). This evidence concerns the gene NUMB and cancer.