In proximity to this genomic locus there are two genes (ARMS2 and HTRA1) which are the strongest AMD risk loci studied so far, though it remains contradictory how these genes influence each other and which are the causal role in the AMD risk (Cheng et al., 2013, Friedrich et al., 2015, Grassmann et al., 2017, Ng et al., 2017). The gene discussed is HTRA1; the disease is age-related macular degeneration.