Indeed, impairment of phagocytosis and renewal of POS induce retina degeneration resembling AMD like phenotypes, as reported in knockout mice such as ATP-binding cassette transporter 4 (ABCA4) or alphavbeta5 integrin (Nandrot et al., 2004, Radu et al., 2004). This evidence concerns the gene ABCA4 and age-related macular degeneration.