Because overexpression of EGFR is observed in the majority of human HNSCC (Leemans et al., 2011; Rieke et al., 2016; Grandis and Tweardy, 1992), HSC3 cells is considered to be a suitable model to recapitulate human EGFR-dependent head-and-neck carcinoma. The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.