HSC3 cells produce tumors in athymic nude mice (Momose et al., 1989; Kudo et al., 2003), and the growth of HSC3 tumor xenografts is inhibited by blocking EGFR activity, indicating that these tumors are EGFR-dependent (Kudo et al., 2003; Shintani et al., 2003). Here, EGFR is linked to neoplasm.