By contrast, in vivo/in vitro ratios of phosphorylation of other signaling effectors, especially STAT3, were significantly higher than these ratios of EGFR and ERK1/2 (Figure 5G), which may be attributable to EGFR-independent activation of the former pathways in HSC3/EGFR-GFP cells in tumors in vivo, and possibly, detection of phosphoproteins in mouse cells contaminating tumor samples. The gene discussed is MAPK3; the disease is neoplasm.