HNF4A and neoplasm: In this study, we speculated that LINC00261 down-regulated β-catenin in nuclei and promoted β-catenin degradation, inactivated Wnt/β-catenin pathway and downstream target genes, then inhibited TCF/LEF/β-catenin complex formation, and finally, repressed colon cancer and reduced the cisplatin resistance of tumor cells.