These results showed that Jak inhibitors prevented uninfected primary CD4 T cells from HIV infection (described in detail under bystander infection assay) and inhibited the production of HIV from infected cells (ruxolitinib antiviral potency with ART; EC50 0.17 μM; EC90 6.2 μM; ruxolitinib antiviral potency without ART; 0.007 μM; EC90 0.26 μM). The gene discussed is CD4; the disease is HIV infectious disease.