ANXA5 and atherosclerosis: After 6 weeks of western diet, ApoE -/- mice treated with AnxA5 revealed a reduction in atherosclerosis development in the aortic root (130027 ± 16988 vs. 83766 ± 9408 μm2 p = 0.0242) as well as the aortic arch (221811 ± 39118 vs. 99770 ± 9922μm2 p = 0,0077) when compared to animals treated with the control compound M1234 (Fig 1A).