EPH-receptor A2 (EPHA2) is a member of the erythropoietin-producing hepatocellular-carcinoma (EPH) sub-family of receptor tyrosine kinases (RTKs) that play critical signaling roles in embryonic development, adult tissue homeostasis, and cancer development and progression [16–20]. The gene discussed is EPHA2; the disease is hepatocellular carcinoma.