Beyond rare mutations, single nucleotide polymorphisms/variants (SNPs/SNVs) across the EPHA2 region have been variably associated with the much more prevalent forms of age-related cataract including cortical cataract, posterior sub-capsular cataract (PSC) and mixed forms of lens opacities in Caucasian/European, Asian/Indian and Chinese populations [26,30, 46–50]. This evidence concerns the gene EPHA2 and Age-related cataract.