In this case, we augment Eq (1) to include a coefficient (CAng) that describes how dependent the tumor growth is on the concentration of the VEGF-VEGFR species (termed “Tumor Growth Model 2”):dV(t)dt=k0*V(t)[1+(k0k1*V(t))ψ]1ψ∙(1−Ang0−CAng∙Ang(t)Ang0)(2)We again applied the eFAST global sensitivity analysis to determine which of the five tumor growth kinetic parameters (k0, k1, ѱ, Ang0, and CAng) significantly influence the predicted tumor volume. The gene discussed is KDR; the disease is neoplasm.