SPP1 and metabolic dysfunction-associated steatotic liver disease: OPN is involved in many liver diseases such as acute liver failure (ALF) [68,69], non-alcoholic fatty liver disease (NAFLD) [70], alcoholic liver disease [71], chronic hepatitis B [72], chronic hepatitis C [73,74], primary biliary cirrhosis [75], and liver fibrosis [76,77,78,79].