SYP and Alzheimer disease: The α2 blockade by mesedin appears also to increase the expression of the pre-synaptic marker of exocytosis, synaptophysin, in neurons, and astroglia from 3×Tg-AD APC, which is logically concordant with the notion that α2 agonists are involved in inhibition of synaptic vesicle exocytosis in hippocampal neurons [56].