Keeping in mind the effect of mesedin on the synaptic marker and the protection of neuronal population against hypoxia in the wild type APC (Figure 3 and Figure 4), we tested the influence of mesedin on the survival of β-tubulin III+/synaptophysin+ neurons and β-tubulin III−/synaptophysin+ astroglia in 3×Tg-AD APC upon exposure of Glu (Figure 8). Here, SYP is linked to Alzheimer disease.