APC and Alzheimer disease: Using the APC from the triple transgenic mouse model of AD exerting plaque and neurofibrillary tangles pathology [58], we demonstrate (1) upregulation of neprilysin, a key degrading enzyme of Aβ, in comparison to the controls with and without Glu; and (2) remarkable inhibition of glutamate-induced intracellular Aβ accumulation in astroglia.