ACE2 and Hyperglycemia: Furthermore, the results verified that the binding of C/EBPβ to the ACE2 promoter decreased following the HG treatment, further indicating that hyperglycaemia‐induced ACE2 down‐regulation may be directly caused by the weaker binding force between C/EBPβ and the ACE2 promoter (P < 0.05; Fig. 7E).