Our data revealed that in the diet switch group, most of the CR‐related features shifted to the MF profile: (i) whole‐body adiposity, (ii) hepatic steatosis, (iii) global transcriptome, and (iv) CR‐specific molecular features including IGF‐1/insulin signaling, oxidative phosphorylation, and AMPK signaling. The gene discussed is INS; the disease is fatty liver disease.