MUC5AC and cancer: For example, sialylated mucin-associated glycans engage the Siglec family of immunomodulatory receptors and may therefore tune the response of critical effector cells in the tumor microenvironment. (Belisle et al., 2010; Ohta et al., 2010; Beatson et al., 2016) Thus, mucins’ influence on cancer likely reflects many functional modalities, each contributing differentially to various facets of disease progression.