MUC1 and metastatic neoplasm: This model unifies the structure of mucins with their consistent overexpression in metastatic disease (Horm and Schroeder, 2013) and the correlation of their overexpression with poor prognosis. (Rahn et al., 2001; Duffy et al., 2000; Retterspitz et al., 2010; McGuckin et al., 1995) As well, importantly, our results imply that drugs targeting the cytoplasmic tail of MUC1 will be missing a key pathophysiologic mechanism.