To that end, in the present report we evaluate a wide range of well known and widely validated oxidative stress parameters (lipid peroxidation, protein oxidation, and total antioxidant capacity), as well as non-enzyme (GSH) and enzyme (SOD, CAT, and GPx) antioxidant defense systems in the SLN of women with breast cancer determined as negative, with micrometastases, or with macrometastases by the OSNA method. This evidence concerns the gene SOD1 and breast carcinoma.