The miR-122 is significantly downregulated in liver cancers and inhibits HCC intrahepatic metastasis by regulation of a disintegrin and metalloprotease family protein ADAM10 and ADAM17.61, 62 The hepatocyte growth factor (HGF) c-Met signaling cascade may involve in HCC metastasis. The gene discussed is ADAM17; the disease is hepatocellular carcinoma.