PLAU and hepatocellular carcinoma: All of them are downregulated in HCC.56 Silencing of miR-1 can not only inhibit HCC growth but also mediate HCC cell invasion by downregulating c-Met.63 The miR-34a inhibits tumor cell migration and invasion by decreasing c-Met-induced phosphorylation of extracellular signal-regulated kinases 1 and 2.64 The miR-23b also inhibits the migration and proliferation ability of HCC cells by downregulating c-Met and urokinase-type plasminogen activator.65 miR-199a-3p induced G1 phase cell cycle arrest and reduced invasive capability by targeting c-Met and mTOR.66