The HGF interacts with c-Met receptor tyrosine kinase and leads to invasive growth by stimulating invasion and protection from apoptosis.56 c-Met oncogene is associated with the aggressive nature and the poor clinical outcomes of many tumors such as HCC.56 c-Met oncogene is regulated by miR-1, miR-34a, miR-23b and miR-199a-3p. This evidence concerns the gene HGF and hepatocellular carcinoma.