These mice develop abnormal responses in both innate and adaptive immune cells, as manifested by splenomegaly, lymphadenopathy, heightened cytokine production and multi-organ inflammation, particularly in the lungs.22–24 The specific roles of myeloid MCPIP1 in the pathogenesis of inflammatory diseases, however, remain unknown. This evidence concerns the gene ZC3H12A and Lymphadenopathy.